Decoding Inflammation
Establishing composite biomarkers through advanced signal processing of consumer-grade sensor data.
"Isolating the invisible signals of health."
Immune diseases are notoriously difficult to manage. Patients often face a "diagnostic odyssey" lasting years, and once diagnosed, management relies on sporadic clinical tests that provide only a snapshot of their health. Inflammation, the core driver of these conditions, fluctuates daily, driven by stress, diet, and environment, yet we lack the tools to monitor it continuously and non-invasively.
"The goal is to be able to isolate different immune areas and measure their inflammation or health status from vagal tone."
Our approach goes beyond basic vitals. We leverage a multi-modal sensor array including Continuous Glucose Monitoring (CGM), sweat analysis, clinical-grade PPG (temp/HRV), and in-ear EEG. Individually, these inputs are noisy and complex. However, they collectively contain the latent immune signals of the body.
The Scientific Foundation: By correlating distal biomarkers with the Cholinergic Anti-inflammatory Pathway, we bridge the gap between wrist-worn sensors and gut health. Since 70% of the immune system resides in the gut (GALT), measuring Vagal Tone via high-fidelity HRV provides a direct, non-invasive window into systemic inflammation.
Imagine standing in a crowded room where dozens of people are talking at once. To a microphone, this is just a wall of noise. But the human brain can focus on a single voice and tune out the rest. In signal processing, this is known as the Cocktail Party Problem.
The body is a noisy room. The heart beats, muscles fire, and the brain buzzes with electrical activity. Our challenge is to isolate the faint "whisper" of the gut-immune system amidst this cacophony. We solve this using FastICA augmented by proprietary sensor fusion—a process that mathematically disentangles mixed signals into their independent sources, allowing us to extract the pure immune signal from the noise of being alive.
The Innovation: While current technology requires abdominal electrodes to measure gut signals (Electrogastrography), our hypothesis is that these enteric signals are present—albeit faintly—in distal biometric data. By applying fusion-enhanced FastICA to subtract the dominant "noise" of the heart and brain from our multi-modal sensor array, we aim to isolate these latent gut-immune rhythms non-invasively. This would allow us to detect flare-ups in Crohn's and Hashimoto's patients long before physical symptoms manifest.
The Engineering Reality: This is not just about applying FastICA. The true challenge lies in temporal synchronization. Aligning millisecond-level EEG data from an earbud with minute-level sweat analysis from a patch—across different device clocks and Bluetooth protocols—requires proprietary sensor fusion algorithms. We have developed a custom synchronization layer that acts as the "conductor," ensuring every data stream enters the processing pipeline in perfect lockstep, a prerequisite for accurate signal separation.
The visualization above demonstrates the core concept:
The impact of immune deficiencies extends far beyond physical symptoms, deeply affecting the lives of patients and their families. The unpredictability of flare-ups creates a constant state of anxiety, disrupting work, education, and social life. Current standard treatments often rely on high-dose corticosteroids or monoclonal antibody therapies, which, while effective, come with significant side effects and financial burdens.
However, many immune deficiencies can be managed—and even put into remission—through precise lifestyle interventions such as diet, sleep optimization, and stress management. The missing link is timing. Without real-time data, patients are flying blind. Biofeedback from our composite biomarkers provides the critical "when" and "what," empowering patients to intervene with lifestyle changes before a flare-up necessitates harsh pharmaceutical intervention.
We are not hardware manufacturers, nor do we claim to have solved every mystery of the human body. Our mission is one of discovery and validation. We are rigorously testing whether these signal processing techniques can reliably isolate biomarkers for a wide spectrum of immune deficiencies.
Our long-term objective is to establish a comprehensive portfolio of composite biomarkers—a "Universal Immune Protocol." By synthesizing inputs from multiple disparate sensors, we aim to provide non-invasive, real-time insights into immune episodes and remission states. While starting as advanced wellness tools, the ultimate goal is to validate these biomarkers as regulated medical aids, democratizing clinical-grade monitoring for everyone.
The Strategic Moat: For hardware partners, the value lies not in the sensors they build, but in the fusion layer we own. Any device can measure a single metric; only Accumulate can synchronize and synthesize inputs from multiple disparate devices into a unified immune score. By licensing our proprietary signal processing libraries, partners can instantly upgrade their devices from "fitness trackers" to "advanced immune-aware wellness tools," bridging the gap between fitness tracking and preventative health.
We are currently moving from "technically possible" to "practically feasible." The challenge is no longer just the math, but the robust application of these algorithms in the messy reality of daily life.
Our ultimate commercialization strategy remains flexible. Whether packaged as an Immune SDK for licensing, integrated directly by smartphone manufacturers, or released as open source for the greater good, our priority is impact. We are building the foundational tools to make immune visibility a standard feature of human existence.